At Hannah Clune Aesthetics, polynucleotide treatments are used to improve skin quality, hydration, and overall skin health — supporting natural regeneration for a fresher, stronger, and more radiant appearance.
Based in Barnstaple, North Devon, all treatments are carried out by an experienced Aesthetic Nurse Prescriber, with a strong focus on safety, precision, and subtle, natural results.
This treatment is ideal for those looking to improve skin quality at a deeper level, particularly in delicate or thinner areas of the skin.
polynucleotides
• Under-eye area (dark circles, crepey skin)
• Overall skin quality and texture
• Fine lines
• Neck and décolletage
• Hands
Polynucleotides are particularly effective for improving skin quality in delicate or thin-skinned areas.
What can polynucleotides help with?
Polynucleotides are derived from purified DNA fragments and work at a cellular level to improve the skin’s environment.
They help to:
• Stimulate fibroblasts (cells responsible for collagen and elastin production)
• Improve hydration
• Support tissue repair
• Enhance skin texture and elasticity
This leads to healthier, stronger skin over time, with results focused on regeneration rather than volume.
HOW DO polynucleotides WORK?
Results are gradual and develop over several weeks.
The aim is to improve overall skin quality, hydration, and resilience, leaving the skin looking fresher, smoother, and more radiant.
WHAT RESULTS CAN I EXPECT?
HOW LONG DO polynucleotides last?
A course of treatments is usually recommended, typically spaced a few weeks apart.
Results and longevity vary between individuals, and maintenance treatments may be required to sustain results.
HOW are polynucleotides METABOLISED IN THE BODY?
Polynucleotides are gradually broken down and cleared by the body through natural physiological processes.
• The injected DNA fragments are broken down into smaller components such as nucleotides and nucleosides
• These are then reused by the body or further metabolised
• Final breakdown products are eliminated naturally through normal metabolic pathways
Polynucleotides do not remain permanently in the body and are fully metabolised over time.
are polynucleotides right for me?
Suitability will be fully assessed during your consultation.
This treatment is particularly suited to those looking to improve skin quality, especially in delicate areas such as under the eyes.
A consultation is recommended to discuss your concerns and create a personalised treatment plan.
FAQs
Will it hurt?
1
You may feel a small pinch or stinging sensation. The treatment is quick and generally well tolerated.
Will i bruise?
2
Bruising and swelling can occur and may last a few days to two weeks.
when will i see results?
3
Results develop gradually over several weeks.
will i look natural?
4
Yes — results are subtle and focused on improving overall skin quality rather than changing facial structure.
is there any downtime?
5
There may be some mild swelling or bruising, but most normal activities can be resumed shortly after treatment.
Safety & Considerations
All treatments are carried out following a full medical consultation.
As with any medical procedure, there are potential risks and side effects, which will be discussed in detail prior to treatment.
Patient Information & Consent
Your safety and understanding are always the priority.
A full consultation is carried out prior to any treatment, where risks, benefits, and suitability are discussed in detail.
If you would like to review the full patient information leaflet in advance, you can download it below:
Download Patient Information & Consent (PDF)
This document includes detailed medical information, potential side effects, and aftercare advice.